Compare over-the-counter heartburn medications, including Histamine-2 (H2) blockers, antacids, and proton pump inhibitors (PPIs). Please speak with your healthcare provider about which treatment may be right for you.
PEPCID® vs ZANTAC 360°®
Both PEPCID® and ZANTAC 360°® are a H2 blocker with the active ingredient famotidine. Famotidine helps relieve heartburn by reducing the amount of acid in the stomach.
PEPCID® is the original famotidine brand and has been clinically proven to be safe and effective at providing fast heartburn relief for 35 years when used as directed. Backed by 50+ clinical studies, PEPCID® is the #1 doctor recommended acid reducer brand in the market. Explore more here — PEPCID® vs ZANTAC 360°®.
Find a Heartburn Medicine that May Be Right for You
Explore the heartburn medicine comparison chart below to compare Maximum Strength PEPCID AC®, Original Strength PEPCID AC® and PEPCID COMPLETE® to ZANTAC 360°® Maximum Strength and ZANTAC 360°® Original Strength, as well as other OTC heartburn medicines. Understand the differences between brands to help determine which over-the-counter heartburn medication might be right for you.
 TUMS® Regular Strength 500 Chewables Calcium Carbonate |
 PRILOSEC OTC ® Tablets Omeprazole |
||
|---|---|---|---|
| BENEFITS | |||
| Classification | H2 Blocker | Antacid | PPI |
| Active Ingredient | Famotidine | Calcium Carbonate | Omeprazole |
| Adult Dosing | 1 tablet | 2-4 tablets | 1 pill every day for 14 days |
| Intended Use | Treats and prevents unexpected heartburn | Treats unexpected heartburn | Treats frequent heartburn |
| Onset of Heartburn Relief | Starts to work in minutes1 | Starts to work in seconds4 | Not intended for immediate relief. Can take up to 1-4 days for full effect |
| Duration of Acid Control or Neutralization | Up to 12 hours2 | Up to 12 hours2 | Up to 24 hours (when taken once daily for 14 days) |
| Prevents Heartburn |
 3 |
No |
No |
| Controls Acid All Night |
2 |
No |
Up to 24 hours (when taken once daily for 14 days) |
| Tablet/Capsule |
Yes |
No |
Yes |
| Chewable Tablet |
No |
Yes |
No |
| Original Famotidine Brand, Clinically Proven Heartburn Relief for 35 Years |
Yes |
No |
No |
| #1 Doctor Recommended Acid Reducer Brand |
Yes |
No |
No |
| #1 Gastroenterologist Recommended Acid Reducer H2 Blocker Brand |
Yes |
No |
No |
| Backed by 50+ Clinical Studies |
Yes |
No |
No |
| FOOTER |
No |
*Based on Tums® Regular Strength 500 Chewables | *Based on Prilosec OTC® tablets |
Why Choose PEPCID®
PEPCID® is an H2 blocker that provides relief for occasional heartburn in just 15-30 minutes and helps control acid all day or all night.* As the #1 doctor recommended and #1 selling brand for preventing and relieve heartburn fast, PEPCID® products contain the active ingredient famotidine, an H2 blocker that helps relieve heartburn by reducing the amount of acid in the stomach. For 35 years backed by 50+ clinical studies, PEPCID® has provided safe and effective heartburn relief when used as directed. Learn more about PEPCID®.
PEPCID® is an FDA approved, safe and effective remedy to relieve symptoms of occasional heartburn when used as directed.
*Based on 9-hour acid control studies during the day and 12-hour acid control studies during the night. Acid control does not imply symptom relief.
PEPCID® provides fast heartburn relief in minutes and lasts all day*. Learn more about the PEPCID® money back guarantee and find the details about our policy here.
* Starts to relieve heartburn in 15-30 minutes. Based on 8 hours of symptom relief studies during the day.
1Starts to relieve heartburn in 15-30 minutes.
2Based on 9 hour acid control studies during the day and 12 hour acid control studies at night. Acid control does not imply symptom relief.
3Prevents heartburn if taken 10-60 minutes before a meal.
4Starts to neutralize acid on contact.
5Prevents heartburn if taken 15-60 minutes before a meal.
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See Why PEPCID® Could Work for You
